{"id":384,"date":"2013-05-29T11:12:49","date_gmt":"2013-05-29T02:12:49","guid":{"rendered":"http:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/?page_id=384"},"modified":"2016-05-12T21:00:34","modified_gmt":"2016-05-12T12:00:34","slug":"endothelial-cell-damage","status":"publish","type":"page","link":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/research\/endothelial-cell-damage\/","title":{"rendered":"\u9ad8\u58c1\u9762\u305b\u3093\u65ad\u5fdc\u529b\u4e0b\u306b\u304a\u3051\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u640d\u50b7\u306e\u5b9a\u91cf\u7684\u8a55\u4fa1"},"content":{"rendered":"

\u9ad8\u58c1\u9762\u305b\u3093\u65ad\u5fdc\u529b\u4e0b\u306b\u304a\u3051\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u640d\u50b7\u306e\u5b9a\u91cf\u7684\u8a55\u4fa1<\/h3>\n

Quantitative Evaluation of Endothelial Cell Damage Under High Wall Shear Stress<\/h3>\n

\u8133\u8840\u7ba1\u75be\u60a3\u306f\u5e73\u621023\u5e74\u5ea6\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u65e5\u672c\u4eba\u6b7b\u4ea1\u6570\u306e\u7b2c4\u4f4d\u3068\u306a\u3063\u3066\u3044\u308b(1)<\/sup>\uff0e\u3053\u306e\u8133\u8840\u7ba1\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u8981\u56e0\u306e10%\u3067\u3042\u308b\u304f\u3082\u819c\u4e0b\u51fa\u8840\u306f\u52d5\u8108\u7624\u306e\u7834\u88c2\u304c\u4e3b\u8981\u56e0\u3067\u3042\u308b\uff0e\u52d5\u8108\u7624\u3084\u52d5\u8108\u786c\u5316\u3068\u3044\u3063\u305f\u8840\u7ba1\u75c5\u5909\u306b\u306f\uff0c\u8840\u6d41\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u58c1\u9762\u305b\u3093\u65ad\u5fdc\u529b(WSS)\u306e\u8840\u7ba1\u5185\u58c1\u3078\u306e\u4f5c\u7528\u304c\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b(2)<\/sup>\uff0e\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u904e\u53bb\u306e\u7814\u7a76(3)<\/sup>\u3067\u958b\u767a\u3055\u308c\u305f\u8840\u7ba1\u640d\u50b7\u8a55\u4fa1\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\uff0c\u8840\u7ba1\u7d44\u7e54\u306b\u5bfe\u3057\u3066WSS\u3092\u8ca0\u8377\u3057\uff0c\u8840\u6d41\u306b\u3088\u308b\u529b\u5b66\u7684\u4f5c\u7528\u304c\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u5b9a\u91cf\u7684\u306a\u8a55\u4fa1\u3092\u884c\u3046\uff0e<\/p>\n

\n

\"image001\"<\/a><\/p>\n

Fig. 1\u3000\u5b9f\u9a13\u88c5\u7f6e\u56f3<\/p>\n

\n

\u3000\u5b9f\u9a13\u30b7\u30b9\u30c6\u30e0\u304a\u3088\u3073\u89b3\u5bdf\u30c7\u30d0\u30a4\u30b9\u306e\u6982\u8981\u3092\u56f31\u306b\u793a\u3059\uff0e\u672c\u30b7\u30b9\u30c6\u30e0\u306f\u8840\u7ba1\u7d44\u7e54\u306b\u5236\u5fa1\u3055\u308c\u305f\u6d41\u308c\u5834\u3092\u8ca0\u8377\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\uff0e\u8840\u7ba1\u5185\u58c1\u89b3\u5bdf\u7528\u30c7\u30d0\u30a4\u30b9\u4e0a\u306b\u56fa\u5b9a\u3057\u305f\u8840\u7ba1\u7d44\u7e54\u306b\uff0c\u30ed\u30fc\u30e9\u30fc\u30dd\u30f3\u30d7\u3092\u7528\u3044\u3066\u99c6\u52d5\u3057\u305f\u6d41\u308c\u306b\u3088\u308bWSS\u3092\u8ca0\u8377\u3059\u308b\uff0e\u30ed\u30fc\u30e9\u30fc\u30dd\u30f3\u30d7\u306b\u3088\u308b\u8108\u52d5\u9664\u53bb\u306e\u305f\u3081\u30d1\u30eb\u30b9\u30c0\u30f3\u30d1\u30922\u3064\u30ed\u30fc\u30e9\u30fc\u30dd\u30f3\u30d7\u4e0b\u6d41\u306b\u8a2d\u7f6e\u3057\u305f\uff0e\u8840\u7ba1\u5185\u58c1\u306e\u72b6\u614b\u306f\uff0c\u86cd\u5149\u5b9f\u4f53\u9855\u5fae\u93e1\u3092\u7528\u3044\u3066\u89b3\u5bdf\u3059\u308b\uff0e\u4f5c\u52d5\u6d41\u4f53\u306f\uff11\u56de\u306e\u5b9f\u9a13\u3042\u305f\u308a2L\u306e\u54fa\u4e73\u985e\u7d30\u80de\u57f9\u990a\u7528\u57fa\u672c\u57f9\u5730\uff08D-MEM\uff09\u306b\u30e1\u30c1\u30eb\u30bb\u30eb\u30ed\u30fc\u30b9\u3092\u6eb6\u89e3\u3055\u305b\uff0c\u7c98\u5ea6\u7d0410cP\u3068\u3057\u305f\u3082\u306e\u3092\u7528\u3044\u305f\uff0e\u6e29\u5ea6\u306f37 \u2103\uff0c\u5727\u529b\u306f100mmHg\u3068\u3057\u305f\uff0e\u8840\u7ba1\u8a66\u6599\u306b\u306f\u514e\u306e\u80f8\u90e8\u5927\u52d5\u8108\u3092\u7528\u3044\u305f\uff0e\u307e\u305fWSS\u306e\u7b97\u51fa\u306b\u306f\u6587\u90e8\u79d1\u5b66\u7701\u6b21\u4e16\u4ee3\uff29\uff34\u57fa\u76e4\u69cb\u7bc9\u306e\u305f\u3081\u306e\u7814\u7a76\u958b\u767a\u201c\u9769\u547d\u7684\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u7814\u7a76\u958b\u767a\u201d(4)<\/sup>\u3067\u958b\u767a\u3055\u308c\u305fMC-BFlow\u3092\u4f7f\u7528\u3057\u305f\uff0e<\/p>\n

\n

\"image002\"<\/a><\/p>\n

Fig. 2 \u5b9f\u9a13\u624b\u9806<\/p>\n

\n

\u3000\u5b9f\u9a13\u65b9\u6cd5\u306f\uff0c\u8840\u7ba1\u7d44\u7e54\u4e0a\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u86cd\u5149\u67d3\u8272\u3057\uff0c\u521d\u671f\u72b6\u614b\u306e\u89b3\u5bdf\u3092\u884c\u3046\uff0e\u89b3\u5bdf\u5f8cWSS\u306e\u8ca0\u8377\u309215\u5206\u884c\u3046\uff0e\u8ca0\u8377\u5f8c\u3082\u3046\u4e00\u5ea6\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u67d3\u8272\u3057\uff0c\u67d3\u8272\u5f8c\uff0c\u521d\u671f\u72b6\u614b\u3068\u540c\u4f4d\u7f6e\u306e\u89b3\u5bdf\u3092\u884c\u3046\uff0e\u3053\u306e\u8ca0\u8377\uff0c\u67d3\u8272\uff0c\u89b3\u5bdf\u30924\u56de\uff0c\u8a0860\u5206\u9593\u306eWSS\u8ca0\u8377\u3092\u884c\u3063\u305f\uff0e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u640d\u50b7\u306e\u8a55\u4fa1\u306f\uff0c\u521d\u671f\u72b6\u614b\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u500b\u6570\u5bc6\u5ea6\u3092100%\u3068\u3057\uff0c\u5404\u89b3\u5bdf\u3054\u3068\u306b\u500b\u6570\u5bc6\u5ea6\u3092\u6e2c\u5b9a\u3057\u8a55\u4fa1\u3092\u884c\u3063\u305f<\/p>\n

\n

\"image003\"<\/a>\u00a0 \u00a0 \u00a0\"image004\"<\/a><\/p>\n

(a)\u3000Low WSS (300dyn\/cm2<\/sup>)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (b)\u3000High WSS(950dyn\/cm2<\/sup>)<\/p>\n

Fig. 3 \u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u500b\u6570\u5bc6\u5ea6<\/p>\n

\n

\u3000\u56f33\u306b\u5b9a\u5e38\u6d41\u8ca0\u8377\u6642\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u500b\u6570\u5bc6\u5ea6\u3092\u793a\u3059\uff0e\u5b9a\u5e38\u6d41\u4f4eWSS\u8ca0\u8377\u3067\u306f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u500b\u6570\u5bc6\u5ea6\u306e\u73fe\u8c61\u306f\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\uff0e\u4e00\u65b9\uff0c\u9ad8WSS\u8ca0\u8377\u3067\u306f2\u30b5\u30f3\u30d7\u30eb\u3067\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u5265\u96e2\u304c\u89b3\u5bdf\u3055\u308c\uff0c\u5927\u304d\u304f\u500b\u6570\u5bc6\u5ea6\u304c\u6e1b\u5c11\u3057\u305f\uff0e\u5927\u5e45\u306a\u500b\u6570\u5bc6\u5ea6\u306e\u73fe\u8c61\u304c\u898b\u3089\u308c\u305f\u9ad8WSS\u30b5\u30f3\u30d7\u30eb3\u3067\u306f\uff0c\u56f34\u306b\u793a\u3059\u901a\u308a\u5c40\u6240\u7684\u306a\u5265\u96e2\u304c\u898b\u3089\u308c\uff0c\u9ad8WSS\u30b5\u30f3\u30d7\u30eb1\u3067\u306f\u56f35\u306b\u793a\u3059\u901a\u308a\u307b\u307c\u5168\u3066\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\u5265\u96e2\u3057\u305f\uff0e<\/p>\n

\n

\"image005\"<\/a><\/p>\n

Fig. 4 \u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u5c40\u6240\u7684\u5265\u96e2( High WSS steady flow sample3)<\/p>\n

\n

\"image006\"<\/a><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0(a) \u521d\u671f\u72b6\u614b\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(b) 15\u5206\u8ca0\u8377\u5f8c\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(c)60\u5206\u8ca0\u8377\u5f8c<\/p>\n

\u3000\u3000\u3000\u3000\u3000Fig.5 \u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u5e83\u7bc4\u56f2\u306b\u6e21\u308b\u5265\u96e2(High WSS steady flow sample1)<\/p>\n

\n

\u3000\u672c\u7814\u7a76\u3067\u306f\uff0c\u8840\u7ba1\u640d\u50b7\u8a55\u4fa1\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\uff0c\u58c1\u9762\u305b\u3093\u65ad\u5fdc\u529b\u304c\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u304a\u3088\u307c\u3059\u5f71\u97ff\u306e\u5b9a\u91cf\u7684\u8a55\u4fa1\u3092\u884c\u3063\u305f\uff0e\u305d\u306e\u7d50\u679c\uff0c\u4f4eWSS(300 dyn\/cm2<\/sup>)\u306e\u8ca0\u8377\u3067\u306f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u500b\u6570\u5bc6\u5ea6\u306e\u6e1b\u5c11\u306f\u751f\u3058\u306a\u3044\u3053\u3068\uff0c\u9ad8WSS(950 dyn\/cm2<\/sup>)\u306e\u8ca0\u8377\u3067\u306f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u5265\u96e2\u304c\u751f\u3058\uff0c\u500b\u6570\u5bc6\u5ea6\u306e\u6e1b\u5c11\u304c\u8d77\u304d\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\uff0e<\/p>\n

\n

\u53c2\u8003\u6587\u732e<\/p>\n

\uff081\uff09\u00a0\u00a0 \u539a\u751f\u52b4\u50cd\u7701\uff0c\u4eba\u53e3\u52d5\u614b\u7d71\u8a08\u3000http:\/\/www.mhlw.go.jp\/<\/p>\n

\uff082\uff09\u00a0\u00a0 \u6797\u9271\u4e09\u90ce, \u30d0\u30a4\u30aa\u30e1\u30ab\u30cb\u30af\u30b9, \u30b3\u30ed\u30ca\u793e, 2000.<\/p>\n

\uff083\uff09\u00a0\u00a0 \u98ef\u7530\u9686\u4e00,\u6771\u4eac\u5927\u5b66\u4fee\u58eb\u8ad6\u6587, 2007.<\/p>\n

\uff084\uff09\u00a0\u00a0 \u6587\u90e8\u79d1\u5b66\u7701\u6b21\u4e16\u4ee3\uff29\uff34\u57fa\u76e4\u69cb\u7bc9\u306e\u305f\u3081\u306e\u7814\u7a76\u958b\u767a\u201c\u9769\u547d\u7684\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u7814\u7a76\u958b\u767a\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

\u9ad8\u58c1\u9762\u305b\u3093\u65ad\u5fdc\u529b\u4e0b\u306b\u304a\u3051\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u640d\u50b7\u306e\u5b9a\u91cf\u7684\u8a55\u4fa1 Quantitative … \u7d9a\u304d\u3092\u8aad\u3080 →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":63,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"page-sidebar-left.php","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/pages\/384"}],"collection":[{"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/comments?post=384"}],"version-history":[{"count":4,"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/pages\/384\/revisions"}],"predecessor-version":[{"id":630,"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/pages\/384\/revisions\/630"}],"up":[{"embeddable":true,"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/pages\/63"}],"wp:attachment":[{"href":"https:\/\/www.oshimalab.iis.u-tokyo.ac.jp\/japanese\/wp-json\/wp\/v2\/media?parent=384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}